The virtual course "Introduction to Systems Biology - Virtual Course - Coursera", is a course with different contents and that offers video classes of Approx. 19 hours to complete. Explore its essential features, and click the orange button to get detailed information on the Coursera e-Learning platform
This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents, and their functions.
Biology is moving from molecular to modular.
As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems.
These systems are the basis for central subcellular processes such as signal transduction, transcription, motility, and electrical excitability.
In turn, these processes come together to exhibit cellular behaviors such as secretion, proliferation, and action potentials.
What are the properties of such cellular and subcellular systems? What are the mechanisms by which the emergent behaviors of systems arise? What kinds of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems? The course will develop multiple lines of reasoning to answer the questions listed above.
Two main strands of reasoning are: the design, execution, and interpretation of multivariate experiments that produce large data sets; quantitative reasoning, models and simulations.
Examples will be discussed to demonstrate "how" functions arise at the cellular level and "why" mechanistic knowledge allows us to predict cellular behaviors that lead to disease states and drug responses.
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Icahn School of Medicine at Mount Sinai
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